Indian Journal of Dermatology
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ORIGINAL ARTICLE
Year : 2009  |  Volume : 54  |  Issue : 3  |  Page : 255-257

Mucocutaneous changes in tuberous sclerosis complex: A clinical profile of 27 Indian patients


1 Departments of Dermatology, Venereology and Leprosy, R.G.Kar Medical College, Kolkata, India
2 Department of Psychiatry, Medical College Calcutta, India

Correspondence Address:
Sudip Kumar Ghosh
P.O. Rajballavpur (Via. Maslandapur), Dist-24, Parganas (N), West Bengal - 743 289
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.55636

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Background: Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disease resulting in a wide array of clinical manifestations, primarily affecting the skin and central nervous system. Mucocutaneous features play a very important role in the recognition of this syndrome. Aims: To review the prevalence and patterns of cutaneous manifestations in tuberous sclerosis, in a group of patients from eastern India. Methods: Observational clinical study on twenty-seven consecutive patients of tuberous sclerosis collected during a period of four years. Results: Most were between 10-20 years of age; the male to female ratio was 2:1. Family history was found in two-thirds. The classical triad of tuberous sclerosis was present in only nine (33.3%) patients. Adenoma sebaceum was the most common cutaneous feature (100%), followed by hypomelanotic macules (92.6%), connective tissue nevi (66.6%), and Koenen's tumors (33.3%). Oral mucosal fibromas were seen in six (22.22%) patients. Fibromatous plaque over forehead and scalp was seen in three patients. Limitation of the study was small size of study sample. Conclusion: Prominent mucocutaneous changes are extremely common manifestation of TSC, which may provide crucial diagnostic clues for primary care physicians.


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