Indian Journal of Dermatology
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REVIEW ARTICLE
Year : 2009  |  Volume : 54  |  Issue : 2  |  Page : 100-109

Biologics : Target - specific treatment of systemic and cutaneous autoimmune diseases


Department of Immunology and Rheumatology, VA Medical Center, Sacramento; Graduate Group Immunology, University of California-Davis, USA

Correspondence Address:
Siba P Raychaudhuri
School of Medicine, University of California-Davis, 1911 Geneva Place, Davis, CA 95618
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.53175

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Biologics are becoming important in the treatment of systemic and cutaneous autoimmune diseases. They are designed to target specific components of immune system. As the new drugs are capable of targeting proteins in a more specific fashion, yet have lower risks of systemic side-effects, they have considerable advantages over the older immunomodulators. The development of TNF-alpha blockers in the treatment of psoriasis, psoriatic arthritis, rheumatoid arthritis, Crohn's disease and ankylosing spondylitis have been major breakthroughs. Likewise, B-cell depletion has proved to be equally revolutionary for the treatment of lupus, pemphigus, certain vasculitides etc. But all said and done, the development of these molecules and their clinical usage are still at evolving stages. Consensus needs be formed to further categorize the clinical profiles of the patients in whom biologics are to be used in the future, given that the long-term safety profiles of these agents are very much unknown at present.


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