Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
 
Users online: 45  
Home  Editorial Board  Current Issue Archives Coming Soon Guidelines Subscriptions  e-Alerts    Login  
    Small font sizeDefault font sizeIncrease font size Print this page Email this page


 
CORRESPONDENCE
Year : 2008  |  Volume : 53  |  Issue : 2  |  Page : 101-102
Cyclosporine in chronic idiopathic urticaria with positive autologous serum skin test


Terna Hospital, Sector 10, Vashi, Navi Mumbai - 400 703, India

Correspondence Address:
K V Godse
Terna Hospital, Sector 10, Vashi, Navi Mumbai - 400 703
India
Login to access the Email id


DOI: 10.4103/0019-5154.41662

PMID: 19882003

Get Permissions



How to cite this article:
Godse K V. Cyclosporine in chronic idiopathic urticaria with positive autologous serum skin test. Indian J Dermatol 2008;53:101-2

How to cite this URL:
Godse K V. Cyclosporine in chronic idiopathic urticaria with positive autologous serum skin test. Indian J Dermatol [serial online] 2008 [cited 2014 Aug 22];53:101-2. Available from: http://www.e-ijd.org/text.asp?2008/53/2/101/41662


This small study evaluates the effectiveness and safety of cyclosporine (CsA) in the treatment of patients with chronic idiopathic urticaria with a positive autologous serum skin test (ASST), who fail to respond to conventional therapy, and requiring long-term oral steroid treatment. This small study evaluates the effectiveness and safety of cyclosporine (CsA) in the treatment of patients with chronic idiopathic urticaria with a positive autologous serum skin test (ASST), who fail to respond to conventional therapy, and requiring long-term oral steroid treatment. Small open-label trials suggest that cyclosporine (CsA), used at a range of different daily dosages (<5 mg/kg) and duration, could be of therapeutic value in patients with chronic idiopathic urticaria (CIU) that is unresponsive to conventional therapy. [1],[2],[3],[4]

Five adult patients (4 females and 1 male) in the age group of 20-50 years with mean age of 37.8 years with severe disease ranging from 6 weeks to 5 years [Table 1], unresponsive to antihistamines and showing a positive ASST, were advised to take 3 mg/kg per day of CsA for 12 weeks after taking consent for treatment, along with cetirizine (10 mg). Exclusion criteria included other concomitant forms of urticaria, any contraindications to cetirizine and CsA, and relevant systemic disorders. The clinical efficacy was measured with an activity score of wheal numbers and itch (Urticaria Activity Score, UAS). All patients were followed up to assess response to treatment.

All patients were reviewed at 0, 2, 4, 8 and 12 weeks with urticaria activity score.

The UAS consists of the sum of the wheal number score and the itch severity score. [5] The wheal numbers are graded from 0 to 3 as follows: 0 - less than 10 small wheals (diameter, <3 cm); 1 - 10 to 50 small wheals or less than 10 large wheals (diameter, >3 cm); 2 - greater than 50 small wheals or 10 to 50 large wheals; and 3 - almost the whole body is covered. The severity of itching is graded from 0 to 3 (0, none; 1, mild; 2, moderate; and 3, severe). Baseline investigations included urine examination, complete blood count, blood sugar, urea, creatinine and serum electrolytes. Repeat tests were done at 2, 4, 8 and 12 weeks. Blood pressure was monitored every two weeks.

Average urticaria activity score was 5.4. Within two weeks of starting cyclosporine, the score came down to 1.6. The male patient discontinued cyclosporine due to high cost of therapy. Score came down to less than one in all four female patients who continued treatment. Side effects were few. In one patient, blood pressure went up 120/90 mm of Hg requiring amlodipine (2.5 mg) therapy. By the end of treatment, 3/4 (75%) patients were in full remission (score 0) and the remainder scored 1.

This uncontrolled study has shown that low-dose CsA is effective in treating CIU patients, and can be given safely for 3 months. One study showed that prolonged treatment with CsA is beneficial for maintaining remission in severe cases of CU. It spares the need for corticosteroids and is accompanied with mild side effects. [6] We could not perform ASST after stopping treatment, but one study from Italy has shown that ASST becomes negative in majority of patients with remission of symptoms. [7] Methotrexate can be used in patients who cannot afford cyclosporine as reported by us. [8]

 
   References Top

1.Fradin MS, Ellis CN, Voorhes JJ. Oral cyclosporine for severe chronic idiopathic urticaria and angioedema. J Am Acad Dermatol 1991;25:1065-7.  Back to cited text no. 1    
2.Barlow RJ, Kobza BA, Greaves MW. Treatment of severe, chronic urticaria with cyclosporine A. Eur J Dermatol 1993;3:273-5.  Back to cited text no. 2    
3.Toubi E, Blant A, Golan TD. Low dose cyclosporine A in the treatment of severe chronic idiopathic urticaria. Allergy 1997;52:312-6.  Back to cited text no. 3  [PUBMED]  
4.Ilter N, Gurer MA, Akkoca MA. Short term oral cyclosporine for chronic idiopathic urticaria. J Eur Acad Dermatol Venereol 1999;12:67-9.  Back to cited text no. 4    
5.Erbagci Z. The leukotriene receptor antagonist montelukast in the treatment of chronic idiopathic urticaria: A single-blind, placebo-controlled, crossover clinical study. J Aller Clin Immunol 2002;110:484-8.  Back to cited text no. 5    
6.Kessel A, Toubi E. Extended cyclosporine A treatment of severe chronic urticaria. Harefuah 2006;145:411-4,471.  Back to cited text no. 6  [PUBMED]  
7.Di Giacchino M, Di Stefano F, Cavallucci E, Verna N, Ramondo S, Paolini F, et al. Treatment of chronic idiopathic urticaria and positive autologous serum skin test with cyclosporine: Clinical and immunological evaluation. Allergy Asthma Proc 2003;24:285-90.  Back to cited text no. 7    
8.Godse K. Methotrexate in autoimmune urticaria. Indian J Dermatol Venereol Leprol 2004;70:377-7.  Back to cited text no. 8    



 
 
    Tables

  [Table 1]

This article has been cited by
1 Chronic Urticaria: Indian Context—Challenges and Treatment Options
Sujoy Khan,Anirban Maitra,Pravin Hissaria,Sitesh Roy,Mahesh Padukudru Anand,Nalin Nag,Harpal Singh
Dermatology Research and Practice. 2013; 2013: 1
[Pubmed]



 

Top
Print this article  Email this article
 
  Search
 
   Next article
   Previous article 
   Table of Contents
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (78 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    References
    Article Tables

 Article Access Statistics
    Viewed3659    
    Printed58    
    Emailed2    
    PDF Downloaded179    
    Comments [Add]    
    Cited by others 1    

Recommend this journal

Site supported by Galderma