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Year : 2006  |  Volume : 51  |  Issue : 3  |  Page : 192-193
Salivary electrolytes in psoriasis: A preliminary study


Department of Dermatology and STD, Sri Devaraj URS Medical College, Tamaka, Kolar - 563 101, Karnataka, India

Correspondence Address:
Gurcharan Singh
# 108, Jal Vaya Vihar, Kammanahalli Main, Bangalore - 560043, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0019-5154.27983

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   Abstract 

Background: There have been few isolated studies on alteration of salivary electrolytes in psoriasis but this subject has not been pursued extensively. Purpose: The present study was conducted to assess any alteration in the levels of salivary electrolytes in psoriasis and to correlate the same with type and severity of the disease. Materials and Methods: Fifteen patients of uncomplicated psoriasis and 12 age and sex matched controls attending the outpatient department of R.L.J.H. and S.N.R. Hospitals, Kolar, India were included for analysis of salivary electrolytes. PASI scoring was used to assess the severity of the disease. Student's t-test ( P <0.05; significant) was utilized for statistical evaluation of results. Results: Salivary sodium levels were significantly elevated in psoriasis ( P value 0.002), whereas there was no significant rise in levels of salivary potassium. However, potassium levels correlated significantly with severity of the disease ( P value 0.043). Conclusion: There was elevation of salivary sodium levels in patients of psoriasis and potassium levels correlated with severity of the disease. Limitation: Unicentre hospital based study with small sample size; hence the results cannot be generalized.


Keywords: Psoriasis, salivary sodium, salivary potassium


How to cite this article:
Singh G, Rajashekar T S, Krishnamurthy, Haneef N. Salivary electrolytes in psoriasis: A preliminary study. Indian J Dermatol 2006;51:192-3

How to cite this URL:
Singh G, Rajashekar T S, Krishnamurthy, Haneef N. Salivary electrolytes in psoriasis: A preliminary study. Indian J Dermatol [serial online] 2006 [cited 2020 Jun 5];51:192-3. Available from: http://www.e-ijd.org/text.asp?2006/51/3/192/27983


Saliva sampling being readily accessible and collectible has gained importance as a non-invasive research technique in the recent years. There have been few isolated studies on alteration of salivary electrolytes in psoriasis but this subject has not been pursued extensively.

Fifteen patients of psoriasis and 12 age and sex matched controls attending the outpatient department of R.L.J.H. and S.N.R. Hospitals, Kolar, India were included in the present study. Salivary samples were collected 2 hours after breakfast, filtered and analyzed for sodium and potassium level by ion selective electrode method. Patients with underlying chronic medical illness and arthritis were excluded from the study. PASI scoring was used to assess the severity of the disease and Student's t-test ( P <0.05; significant) was utilized for statistical evaluation of results.

Salivary sodium levels were significantly elevated in psoriasis (mean value of 27.80 mM in test subjects against 18.75 mM in controls, P value 0.002), whereas rise in salivary potassium level was not significant (mean value of 11.52 mM in test subjects against 10.10 mM in controls, P value 0.35). However, potassium levels correlated significantly with severity of the disease ( P value 0.043). Alteration of salivary electrolytes was more significant in guttate variant of the disease [Table 1].

Structure and function of salivary glands seems to be unaffected in psoriatics, as no impairment in salivary secretion was notable in a study.[1] However median maximal stimulated salivary flow rate was significantly reduced in patients with psoriatic arthropathy.[2] Alteration of salivary constituents on chemical analysis of saliva in psoriatics has been documented. A significant elevation of salivary IgA, alpha-amylase and sodium was found in psoriatics unlike in the controls,[3] and the possible role of cAMP and neural regulation in the causation of elevated amylase and sodium levels in psoriatics was hypothesized.[2] Elevation of salivary sodium and potassium levels in psoriasis and reduction of salivary sodium content after ultraviolet therapy has been reported.[4]

Elevation of salivary sodium and correlation of potassium levels with PASI scoring was significant in the present study. Further studies are required to ascertain diagnostic and prognostic value of these observations in psoriasis.



 
   References Top

1.Syrjanen S, Syrjanen K, Horsmanheimo M. Structure and function of salivary glands in psoratics. Arch Dermatol Res 1982;274:295-301.  Back to cited text no. 1  [PUBMED]    
2.Collen P, Rogers S, Jackson S, McCartan B. Psoriasis, psoriatic arthritis and the possible association with Sjogren syndrome. Br J Dermatol 1992;126:242-5.  Back to cited text no. 2      
3.Syrjanen SM. Chemical analysis of parotid saliva and lacrimal fluid in psoriatics. Arch Dermatol Res 1983;275:152-5.   Back to cited text no. 3  [PUBMED]    
4.Wanjura HJ. Psoriasis and sodium chloride. Derm Beruf Umwelt 1986;34:41-2.  Back to cited text no. 4  [PUBMED]    



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