Indian Journal of Dermatology
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Year : 2003  |  Volume : 48  |  Issue : 2  |  Page : 68-72

High Frequency Of Thyroid Dysfunction In Indian Patients With Vitiligo



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Shriya Dave


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This Study was carried out look for any association of vitiligo with autoimmune thyroid disease and to find out clinical characteristics of vitiligo, which may predict such and association. Thirty-five consecutive cases of vitiligo were enrolled for this study. Besides recording the clinical features of vitiligo and thyroid disease, antithyroid autoantibody assays (anthi-thyroglobulin, anti-TPO) and thyroid hormone profiles were done in these cases and 30 appropriately age and sex matched controls. Radioactive iodine uptake (RAIU) thyroid scintiscan was done for all the cases and controls. Amongst the vitiligo cases, vitiligo vulgaris was the commonest type (45.70%), while mucosal vitiligo constituted 22.8% of cases. No Patient was found to have thyroid disease clinically; however, on assays, thyroid abnormality (endocrine, immunological or both) was found in 57.1% of the cases as against 10% of the controls (p<0.05). Autonatibody positivity was found in 31.4% of the cases as against 10% of the controls (p<0.05). Biochemical abnormality (predominantly hyperthyroidism) was found in 40% of the cases as against 6.7% of the controls (p<0.05). Four patients with hyperthyroidism showed diffuse increase in uptake on RAIU scan and auto antibody poisitivity, thus were diagnosed as Grave’s disease. An early age at onset was found in patients with thyroid disease. Mucosal vitiligo was found in 35% of the cases with thyroid dysfunction as against 6.7% in those without (p<0.05) with was the most unique finding of the study. To conclude, we would like to stress that patients with vitiligo should be screened for thyroid dysfunction, especially those with mucosal vitiligo.


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