Indian Journal of Dermatology
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Year : 2003  |  Volume : 48  |  Issue : 1  |  Page : 30-32

Dapsone Syndrome : Revisited



Correspondence Address:
Shriya Dave


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A retrospective analysis of all cases of dapsone syndrome, which presented to us between January 1997 to June 2002, was done using the patients case records. An attempt was made to characterize the clinical profile, therapeutic and prognostic aspects of each case. Overall, sixteen cases of dapsone syndrome were seen. The male to female ratio was 1.3:1 (males-9, females-7). The mean age of these cases was 34.8 years(range 11 to 57 years). All patients had taken dapsone for periods ranging form 2 to 300 days, average being 60.2 days. Of the sixteen cases, 7 had confirmed Hansen’s disease (borderline tuberculoid leprosy-5, borderline lepromatous leprosy-1, indeterminate leprosy-1), 8 cases had been suspected of having leprosy while one case had lichen planus. Mucocutaneous manifestations were present in all cases. Systemic manifestations included fever, pallor, icterus, lumphadenopathy, hepatomegaly splenomegaly and ascites. Of the sixteen cases with dapsone syndrome, 14 had a favourable outcome. Of the two patients who expired, one developed septicaemia with nephrotic syndrome while the other progressed to toxic epidermal necrolysis and succumbed to complications thereof (septicaemia)


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