Indian Journal of Dermatology
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Year : 2003  |  Volume : 48  |  Issue : 1  |  Page : 18-21

Dexamethasone Cyclophosphamide Pulse Therapy In Pemphigus- A Five Year Retrospective Study



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Alka Dogra


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The present retrospective study comprised 71 patients of pemphigus enrolled for dexamethasone- cyclophosphamide or plain dexamethasone pulse therapy between January 1997 to December 2001. Ten patients were lost to follow up, 2. expired and treatement was withheld in 2 patients due to side effects. Fifty-seven patients are on regular follow up. The type of pemphigus was P. vulgaris in 48, P. foliaceous in 6, P. erythematosus in I and P. herpetiformis in 2. Of 57 patients, 2 were in phase –1,3 in phase II, 9 phase – III and 43 phase – IV treatment. The type of pemphigus and the duration of the disease were found to influence the response to treatment. Main side effects encountered included candidiasis, diarrhoea, pyodermas, facial flushing, dermatophytosis and hiccups. Pulse therapy had to be stopped in 2 patients, because of cataract and psychosis in one patient each. Serious side effects seen were pancytopenia in one patient and septicaemia in another, both of whom died. Relapse was seen in 2 patients.


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