Indian Journal of Dermatology
  Publication of IADVL, WB
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Year : 1991  |  Volume : 36  |  Issue : 2  |  Page : 47-53

Controlled clinical trial of celestone vis-A-vis its components in allergic skin disorders


Dept. Of Dermatology Grant Medical College and Hon Dermatologist J.J. Hospital and Inlaks General Hospitals, Bombay

Correspondence Address:
C Oberai
Dept. Of Dermatology Grant Medical College and Hon Dermatologist J.J. Hospital and Inlaks General Hospitals, Bombay

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Source of Support: None, Conflict of Interest: None


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ABSTRACT: A randomised, parallel-group clinical study was undertaken to compare the efficacy of Celestamine tablet, Celestone tablet, Celestone 1/2 tablet and Polaramine tablet in allergic skin disorders of at least a moderate severity. Either drug was administered thrice daily for 14 days. Every patient reported for clinical examination and evaluation four times viz. just before starting therapy (Day 0) and at the end of 2,7 and 14 days' treatment. Clinical improvement in the individual symptoms on a 4-point scale and the total symptom score were used to compare the efficacy. Out of the 323 patients successfully completing this study there were 84,82,79 and 78 respectively on each drug. Every drug produced a statistically progressive improvement during each of the three follow-up visits. However, Celestamine tablet or Celestone tablet was significantly superior to the individual components of the former. Celestamine offers a synergistic and steroidsparing effect. No adverse effects were reported by any patient in this study.


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