Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
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Year : 1991  |  Volume : 36  |  Issue : 2  |  Page : 28-35

Double-blind comparative clinical efficacy and safety study of betamethasone dipropionate (0.05 percent) and betamethasone valerate (0.12 percent) in the treatment of steroid-responsive dermatoses


Department of Dermatology and Venereology, Moulana Azad Medical College and Associated LNJPN and GB Pant Hospital New Delhi, India

Correspondence Address:
VN Sehgal
Department of Dermatology and Venereology, Moulana Azad Medical College and Associated LNJPN and GB Pant Hospital New Delhi
India
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Source of Support: None, Conflict of Interest: None


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ABSTRACT: In a double-blind study, betamethasone dipropionate (0.05 percent) and betamethasone valerate (0.12 percent) were randomly evaluated in eczemas and other steriod-responsive dermatoses. The former was dispensed in a propylene glycol vehicle, while the latter had the usual non-greasy ointment basic. The improvement was assessed by the reduction in erythema, induration and pruritus in the course of 3 weeks. It was apparent from the analysis of the data that the preceding parameters in patients on Cream-A showed a statistically significant improvement over those receiving Cream-B week by week. Further the overall assessment showed a remarkable response in patients in patients on Cream-A. The side effects of Cream-A included transient sensation of burning or stinging. The Cream-B in addition, caused local swelling, pain and pruritus in some of the patients.


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