Indian Journal of Dermatology
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Year : 1991  |  Volume : 36  |  Issue : 1  |  Page : 1-9

Assessment of the influence of adrenal glands and corticosteroids on the sebaceous gland activity in mice


Department of zoology, university of Kalyani, Kalyani-741235, India

Correspondence Address:
B Bhattacharya
Department of zoology, university of Kalyani, Kalyani-741235
India
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Source of Support: None, Conflict of Interest: None


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ABSTRACT: Adrenalectomy alone in adult male Swiss albino A mice failed to exert any effect on the size (area) of the isolated sebaceous gland from the skin of the back region. Cell renewal and cell growth pattern of this organ as well as the daily sebum production rate also remained unchanged, In the intact, adrenalectomized and castrated-adrenalectomized mice, administration of corticosterone for 15 days at the dose of 100 miug each on alternate day produced a mild effect on the overall activity of sebacuons glands. But in the castrated specimens corticosterone treatment promoted glandular hypertrophy and caused acceleration in the tempo of cell division and cell growth associated with the lipogenic differentiation. This steroid also induced enhancement in the sebum production rate. Identical treatment of Desoxycorticosterone acetate was found to be ineffective in causing any change in the overall activity of sebaceous glands in any group of mice. Gross composition of sebum (assessed by TLC and quantitative densitometry) remained unaltered following removal of testes and/or adrenals as well as after corticosteroid treatments.


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