Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
Indexed with Science Citation Index (E) , Web of Science and PubMed
 
Users online: 2695  
Home About  Editorial Board  Current Issue Archives Online Early Coming Soon Guidelines Subscriptions  e-Alerts    Login  
    Small font sizeDefault font sizeIncrease font size Print this page Email this page
Year : 1990  |  Volume : 35  |  Issue : 4  |  Page : 218-226

Cutaneous manifestations of neuro fibromatosis type 1 m south India


Dpt. of Dermatology and STD; Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India

Correspondence Address:
B Jeevankumar
Dpt. of Dermatology and STD; Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

ABSTRACT: Neurofibromatosis type 1 (NF-1) is the most common form of neurofibromatosis. Since the significance of various cutaneous manifestations of NF-1 has not been known in Indian population, hence, the present study was undertaken. A total of patients with NF-1 were identified between August 1998 to June 2000 with a prevalence rate of 20.04 per 10,000 individuals attending our clinic. Male to female ratio was 2.3:1. The age of the patients ranged from 15 to 70 years with a mean age of 29.57 years. Most patients (18 cases) belonged to age group of 21-30 years followed by 11-20 years age group (11 cases). Twenty four cases had onset of disease between 11-20 years of age and ten cases in 21- 30 years age group. Thirty one of 40 cases presented with asymptomatic nodules, three sought medical opinion for cosmetic reasons and another three for hyperpigmented patch. Analysis of cutaneous manifestations showed. 39 of 40 cases (97.5 percent) had neurofibromas. Palmar melanotic macules were noted in 36 (90 percent) cases whereas cafe-au-lait macules were seen in 33 (82.5 percent) cases. Subsequent less common findings were intertriginous freckles in 31 (77.5 percent) cases, plantar melanotic macules in 18 (45 percent) cases and generalised freckles in 4(10 percent) cases. Statistical analysis of cases and controls revealed significant association of NF-1 with neurofibromas, palmar melanotic, cafe-au-lait macules, intertriginous freckles and plantar melanotic macules (p0.001). This study brings into focus some of the cutaneous manifestations noted in South Indian patients especially palmar and plantar melanotic macules, not highlighted in the western literature.


[PDF Not available]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2304    
    Printed57    
    Emailed0    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal